ABSTRACT
Pleomorphic adenoma occurs commonly in the major salivary glands but is uncommonly encountered in the breast. In both of these locations, the tumor is typically grossly circumscribed and has a ―mixed‖ histological appearance, being composed of myoepithelial and epithelial components amid a myxochondroid matrix. Pleomorphic adenoma of the breast is a rare, benign tumor accounting for 68 cases in the literature. It is most commonly seen in postmenopausal women. Here, we have reported a case of mammary pleomorphic adenoma in an asymptomatic 45-year-old woman which was preoperatively thought to represent a carcinoma on clinical and radiological grounds. It is the rarity of the tumor in the breast, rather than its histological appearance, that causes diagnostic difficulty.
ABSTRACT
Anaplastic thyroid carcinoma (ATC) is a rare, highly malignant thyroid tumor with dismal prognosis. Its usual presentation is in elderly patients as a very rapidly growing mass. ATC mainly shows three patterns: spindle cells, giant cell and squamoid but these three subtypes frequently coexist. Osteoclastic giant cell variant of ATC is extremely rare and is characterized by the presence of a large number of multinucleated giant cells resembling osteoclasts. We are reporting here this unusual variant in a 67-year-old male with a history of progressively increasing midline neck swelling and pulmonary metastasis and left jugular vein thrombosis. Cytologically, many multinucleated osteoclast-like giant cells were seen accompanying the malignant spindle cell component.